Exploiting the natural metabolic diversity of Streptomyces venezuelae to generate unusual reduced macrolides.

نویسندگان

  • Je Won Park
  • Hong-Se Oh
  • Won Seok Jung
  • Sung Ryeol Park
  • Ah Reum Han
  • Yeon-Hee Ban
  • Eun Ji Kim
  • Han-Young Kang
  • Yeo Joon Yoon
چکیده

An unusual set of reduced macrolide antibiotics was discovered by combination of organic synthesis and a biosynthetic approach using the unique metabolic diversity of Streptomyces venezuelae; two unnatural 16-membered ring macrolides are also created by employing this bio-catalyst.

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A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.

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عنوان ژورنال:
  • Chemical communications

دوره 44  شماره 

صفحات  -

تاریخ انتشار 2008